Extracellular matrix receptors in branched organs
نویسندگان
چکیده
منابع مشابه
Extracellular matrix molecules and their receptors: functions in neural development.
The development of neurons and virtually all other cell types in the organism depends upon interactions with molecules in their environment. Studies of individual cell types have revealed tremendous diversity in the molecules that regulate the development of cells in the nervous system. These include chemotropic and trophic factors [e.g. nerve growth-factor (NGF) and brain derived neurotrophic ...
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The major cellular constituents of the mammalian peripheral nervous system are neurons (axons) and Schwann cells. During peripheral nerve development Schwann cells actively deposit extracellular matrix (ECM), comprised of basal lamina sheets that surround individual axon-Schwann cell units and collagen fibrils. These ECM structures are formed from a diverse set of macromolecules, consisting of ...
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Fibroblasts in 2D cultures differ dramatically in behavior from those in the 3D environment of a multicellular organism. However, the basis of this disparity is unknown. A key difference is the spatial arrangement of anchored extracellular matrix (ECM) receptors to the ventral surface in 2D cultures and throughout the entire surface in 3D cultures. Therefore, we asked whether changing the topog...
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Extracellular matrix molecules help regulate many aspects of neural development, including survival, migration, axon growth, and synapse formation by neurons. These same molecules have been shown to modulate regeneration of neurons after injuries. They also regulate the development and differentiation of other neural cells, such as astroglia and Schwann cells. Significant progress has been made...
متن کاملExtracellular Matrix
The tissues of a multicellular organism contain two main components, the cells themselves, onwhichmost biological research has traditionally focused, and the material that lies between the cells. This material is called the extracellular matrix, usually abbreviated to ‘ECM’. The ratio of tissue volume occupied by ECM to that occupied by cells varies from less than 1:10 (e.g. in muscles) to more...
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ژورنال
عنوان ژورنال: Current Opinion in Cell Biology
سال: 2011
ISSN: 0955-0674
DOI: 10.1016/j.ceb.2011.04.003